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Gambogenic acid
CAS No. 173932-75-7
Gambogenic acid ( GNA )
Catalog No. M12639 CAS No. 173932-75-7
Gambogenic acid (GNA) is a polyprenylated xanthone isolated from gamboge.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 197 | Get Quote |
|
| 10MG | 340 | Get Quote |
|
| 25MG | 561 | Get Quote |
|
| 50MG | 794 | Get Quote |
|
| 100MG | 1062 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGambogenic acid
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NoteResearch use only, not for human use.
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Brief DescriptionGambogenic acid (GNA) is a polyprenylated xanthone isolated from gamboge.
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DescriptionGambogenic acid (GNA) is a polyprenylated xanthone isolated from gamboge, shows potent antitumor activity and can effectively inhibit the survival and proliferation of cancer cells; specifically and covalently binds to Cys668 within the EZH2-SET domain, trigges EZH2 degradation (IC50=8.6 uM) through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination; synergistically potentiates bortezomib-induced apoptosis in multiple myeloma; also induces proteasomal degradation of CIP2A and sensitizes hepatocellular carcinoma to anticancer agents.
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SynonymsGNA
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number173932-75-7
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Formula Weight630.78
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Molecular FormulaC38H46O8
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)/C(C)=C\C[C@]([C@@]12OC3=C4C(O)=C(C/C=C(C)/CC/C=C(C)\C)C(O)=C3C/C=C(C)\C)(OC(C)(C)[C@]2([H])C5)C([C@]5([H])C=C1C4=O)=O
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Chemical Name(Z)-4-((1S,3aR,5S,12aS)-9-((E)-3,7-dimethylocta-2,6-dien-1-yl)-8,10-dihydroxy-2,2-dimethyl-11-(3-methylbut-2-en-1-yl)-4,7-dioxo-1,2,5,7-tetrahydro-1,5-methanofuro[2,3-d]xanthen-3a(4H)-yl)-2-methylbut-2-enoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xu L, et al. Cell Death Dis. 2018 Feb 15;9(3):262.
2. Liu P, et al. J Cancer. 2017 Sep 16;8(16):3278-3286.
3. Wang X, et al. EMBO J. 2017 May 2;36(9):1243-1260.
4. Li F, et al. Exp Ther Med. 2017 May;13(5):2456-2462.
2. Liu P, et al. J Cancer. 2017 Sep 16;8(16):3278-3286.
3. Wang X, et al. EMBO J. 2017 May 2;36(9):1243-1260.
4. Li F, et al. Exp Ther Med. 2017 May;13(5):2456-2462.
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