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Home - Products - Chromatin/Epigenetic - HMTase - Gambogenic acid

Gambogenic acid

CAS No. 173932-75-7

Gambogenic acid ( GNA )

Catalog No. M12639 CAS No. 173932-75-7

Gambogenic acid (GNA) is a polyprenylated xanthone isolated from gamboge.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 197 Get Quote
10MG 340 Get Quote
25MG 561 Get Quote
50MG 794 Get Quote
100MG 1062 Get Quote
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Biological Information

  • Product Name
    Gambogenic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Gambogenic acid (GNA) is a polyprenylated xanthone isolated from gamboge.
  • Description
    Gambogenic acid (GNA) is a polyprenylated xanthone isolated from gamboge, shows potent antitumor activity and can effectively inhibit the survival and proliferation of cancer cells; specifically and covalently binds to Cys668 within the EZH2-SET domain, trigges EZH2 degradation (IC50=8.6 uM) through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination; synergistically potentiates bortezomib-induced apoptosis in multiple myeloma; also induces proteasomal degradation of CIP2A and sensitizes hepatocellular carcinoma to anticancer agents.
  • Synonyms
    GNA
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    173932-75-7
  • Formula Weight
    630.78
  • Molecular Formula
    C38H46O8
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)/C(C)=C\C[C@]([C@@]12OC3=C4C(O)=C(C/C=C(C)/CC/C=C(C)\C)C(O)=C3C/C=C(C)\C)(OC(C)(C)[C@]2([H])C5)C([C@]5([H])C=C1C4=O)=O
  • Chemical Name
    (Z)-4-((1S,3aR,5S,12aS)-9-((E)-3,7-dimethylocta-2,6-dien-1-yl)-8,10-dihydroxy-2,2-dimethyl-11-(3-methylbut-2-en-1-yl)-4,7-dioxo-1,2,5,7-tetrahydro-1,5-methanofuro[2,3-d]xanthen-3a(4H)-yl)-2-methylbut-2-enoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xu L, et al. Cell Death Dis. 2018 Feb 15;9(3):262.
2. Liu P, et al. J Cancer. 2017 Sep 16;8(16):3278-3286.
3. Wang X, et al. EMBO J. 2017 May 2;36(9):1243-1260.
4. Li F, et al. Exp Ther Med. 2017 May;13(5):2456-2462.
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